O Laboratório de Biologia Molecular (LBM) foi criado em 2007 através de um projeto de pesquisa para a prospecção de genes de micro-organismos de interesse da região Nordeste. Desde então, vem desenvolvendo pesquisas nas áreas de Expressão Gênica de Microrganismos, Antimicrobianos, Cultura de células, Fitocompostos, Biodegradação e Biorremediação.
E-mail: lbm@itp.org.br
Contato: (79) 3218 2190 R 2696
Dra. Maria Lucila Hernández MacedoMENEZES, D. B.; BRAZIL, O. A.; ROMANHOLO-FERREIRA, L. F.; POLIZELI, M. L. T.; RUZENE, D. S.; SILVA, D. P.; COSTA, L. P.; HERNÁNDEZ-MACEDO, MARIA L.. Prospecting fungal ligninases using corncob lignocellolytic fraction. CELLULOSE, v. 8, p. 1-11.
GASPAR, L. M. A.; ALVES, L.; DROPPA-ALMEIDA, D.; HERNÁNDEZ-MACEDO, M L; PADILHA, F. F.. Development and characterization of PLGA nanoparticles containing antibiotics. JOURNAL OF NANOPARTICLE RESEARCH, v. 20, p. 289.
SILVA, J. R. O.; SANTOS, D. S.; SANTOS, U. R.; EGUILUZ, K. I. B.; SALAZAR-BANDA, G. R.; SCHNEIDER, J. K.; KRAUSE, L. C.; LÓPEZ, J. A.; HERNANDEZ-MACEDO, M. L.. Electrochemical and/or microbiological treatment of pyrolysis wastewater. CHEMOSPHERE, v. 185, p. 145-151.
LUSTOSA, M. A.; LÓPEZ, J. A.; FREIRE, K. C. S.; Padilha, F.F.; HENANDEZ-MACEDO, M. L.; CABRERA-PADILLA, R. Y.. Petroleum hydrocarbon degradation by isolated mangrove bacteria. Revista Peruana de Biología (En Línea), v. 25, p. 453-456.
FERNANDES, T. G.; LÓPEZ, J. A.; SILVA, L. A.; POLIZELI, M. L. T. M.; SILVA, D. P.; RUZENE, D. S.; CARVALHO, M. L. S.; CARVALHO, I. F.. Prospecting of soybean hulls as an inducer carbon source for the cellulase production. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v. 48, p. 743-749.
FERREIRA, C. S. ; JESUS, I. B. ; ALMEIDA, D. D. ; VIVAS, W. L. P. ; BORSUK, S. ; DELLAGOSTIN, O. A. ; Lima-Verde, I.B. ; LÓPEZ, J. A. ; NASCIMENTO, R. J. M. ; Padilha, F.F. ; ALMEIDA, E. B. . PROTEÍNA RECOMBINANTE DE CORYNEBACTERIUM PSEUDOTUBERCULOSIS PARA UTILIZAÇÃO EM COMPOSIÇÃO VACINAL E KIT DE DIAGNÓSTICO SOROLÓGICO PARA LINFADENITE CASEOSA. 2015, Brasil.
SANTOS, J. M.; CURY, N. M.; YUNES, J. A.; LÓPEZ, J. A.; HERNANDEZ-MACEDO, M. L. Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines. Natural Products Research, v. 16, p. 1-4.
ZENI, P.; SANTOS, D.; CANEVAROLO, R. R.; YUNES, J. A.; Padilha, F.F.; ALBUQUERQUE JUNIOR, R. L. C.; EGUES, S. M.; HERNÁNDEZ-MACEDO, MARIA L . Photocatalytic and Cytotoxic Effects of Nitrogen-Doped TiO2 Nanoparticles on Melanoma Cells. Journal of Nanoscience and Nanotechnology, v. 18, p. 3722-3728.
SENES-LOPES, T. F.; LÓPEZ, J. A.; AMARAL, V. S.; BRANDAO-NETO, O.; REZENDE, A. A.; LUZ, J. R. D.; GUTERRES, Z. R.; ALMEIDA, M.G. Genotoxicity of Turnera subulata and Spondias mombin x Spondias tuberosa Extracts from Brazilian Caatinga Biome. Journal of Medicinal Food, v. 21, p. 372-379.
LIMA, Z. M.; TRINDADE, L. S.; SANTANA, G. C.; Padilha, F.F.; MENDONCA, M. C.; Costa, L. P.; LÓPEZ, J. A.; HERNANDEZ-MACEDO, M. L. Effect of Tamarindus indica L. and Manihot esculenta Extracts on Antibiotic-Resistant Bacteria. PHARMACOGNOSY RESEARCH, v. 9, p. 195-199.
MENDONÇA-LIMA, FERNANDA WASHINGTON; SANTOS, ROBERTO BORGES DOS; SANTOS, LUCIANO CEZAR; Zacharias, Farouk; David, Jorge Maurício; David, Juceni Pereira; LÓPEZ, Jorge Alberto. Anthelmintic activity of Cratyliamollis leaves against gastrointestinal nematodes in goats. Revista Brasileira de Saúde e Produção Animal, v. 17, p. 753-762.
HERNADEZ-MACEDO, M. L.; LÓPEZ, J. A.; RIBEIRO, M. L.; PEDRAZZOLI JR, J.; MELLO, M. P. Study of the gene expression of Ceriporiopsis subvermispora during wood degradation. International Journal of Food, Agriculture and Environment (Online), v. 13, p. 232-237.
Silva GA; Brito, N.J.N.; SANTOS, E. C. G.; LÓPEZ, J. A.; ALMEIDA, M.G. Gênero Spondias: Aspectos botânicos, composição química e potencial farmacológico. Biofar: Revista de Biologia e Farmácia, v. 10, p. 1-15.
KALEGARI, MILENA; GEMIN, CARLOS ALBERTO BRUEL; ARAÚJO-SILVA, GABRIEL; BRITO, Naira Josele Neves de; LOPEZ, J. A.; OLIVEIRA TOZETTO, SIBELE DE; ALMEIDA, Maria das Graças; MIGUEL, MARILIS DALLARMI; STIEN, DIDIER; MIGUEL, OBDULIO GOMES. Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats. Nutrition (Burbank, Los Angeles County, Calif.), v. 30, p. 713-718.
S FERREIRA, DAVI; MENEZES RESENDE, IANE T; LOPEZ, JORGE A. Proteome investigation of an organellar fraction of Toxoplasma gondii: a preliminary study. BMC Proceedings, v. 8, p. P74-P75.
NASCIMENTO BARBOSA, SHÁSKYATANYARA; LIMA, ZENON M.; CALIXTO, PRISCILA; SANTOS, UBIRATAN; CARDAMONE DINIZ, LEANDRO; LÓPEZ, JORGE A.; CAZZANIGA, RODRIGO; HERNÁNDEZ-MACEDO, MARIA. Gene expression of Ceriporiopsissubvermispora during lignocellulosic substrate degradation. BMC Proceedings, v. 8, p. P170-P171.
FERREIRA, DAVI DA S; DE SOUZA COSTA, LARISSA A.; CAMPOS, MÁRCIO; BISPO, MOZART D.; KRAUSE, LAIZA C.; HERNÁNDEZ MACEDO, MARI; LOPEZ, JORGE A. Production of xanthan gum from soybean biodiesel: a preliminary study. BMC Proceedings, v. 8, p. P174-P175.
BRANDÃO, LILLIAN B.; LOPEZ, JORGE A; ASSIS, DENILSON J.; ECHEVARRIA, EMILIANO M ; DRUZIAN, JANICE I . Biosynthesis of xanthan gum from residual glycerin from biodiesel production for drilling fluids. BMC Proceedings, v. 8, p. P187-P188.
SILVA, JUDSON W ; DROPPA-ALMEIDA, DANIELA ;BORSUK, SIBELE; AZEVEDO, VASCO;PORTELA, RICARDO W; MIYOSHI, ANDERSON ; ROCHA, FLÁVIA S.; DORELLA, FERNANDA A.; VIVAS, WANESSA L.; PADILHA, FRANCINE F.; HERNÁNDEZ-MACEDO, MARIA L.; LIMA-VERDE, ISABEL B.. Corynebacterium pseudotuberculosis cp09 mutant and cp40 recombinant protein partially protect mice against caseous lymphadenitis. BMC Veterinary Research, v. 10, p. 965.
HERNÁNDEZ- MACEDO, MARIA; NUNES BARRETO, ERICK; DE SOUZA CAVALCANTI, ANA; DA SILVA, RAFAEL; DOS ANJOS BRANDÃO, ERIKA; MIRANDA FERNANDES, ROBERTA; TALAMINI, VIVIANE; CARDAMONE DINIZ, LEANDRO; FERNANDES, MARCELO. Antimicrobial potential of Actinomycetes by NRPS and PKS-I pathways. BMC Proceedings, v. 8, p. P175.
NASCIMENTO BARBOSA, SHÁSKYATANYARA; LIMA, ZENON M; CALIXTO, PRISCILA; SANTOS, UBIRATAN; CARDAMONE DINIZ, LEANDRO; LÓPEZ, JORGE A; CAZZANIGA, RODRIGO; HERNÁNDEZ-MACEDO, MARIA. Gene expression of Ceriporiopsissubvermispora during lignocellulosic substrate degradation. BMC Proceedings, v. 8, p. P170.
BARBOSA, ANDRIELE; SANTOS, KLEBSON; PINHEIRO, MALONE; MÉLO SILVA, ISABELLE; DE MENDONÇA, FLÁVIA; DIZ, FERNANDO; TABOSA ANDRADE, LUZIA; TAINARA MENEZES, RESENDE; FONSECA, RAFAELA; CARDOSO, JULIANA; HERNANDEZ MACEDO, MARIA; PADILHA, FRANCINE. Production and characterization of films from nanocomposite coating of sunflower seeds. BMC Proceedings, v. 8, p. P225.
ARAGÃO, MONIKY; MENEZES, DIEGO; OLIVEIRA, HELON; SOUZA, JAQUELINE; VITAL-BRAZIL, OSIRIS; ROMANHOLO-FERREIRA, LUIZ; MONTEIRO, REGINA; QUEIJEIRO-LOPEZ, ANA; TEIXEIRA, JOSÉ; HERNANDEZ-MACEDO, MARIA; RUZENE, DENISE; SILVA, DANIEL. Bioremediation of distillery effluent by Pleurotus sajor-caju: evaluation of the influence of pH in vinasse derived from molasses. BMC Proceedings, v. 8, p. P190.
FERREIRA, DAVI DA S; DE SOUZA COSTA, LARISSA A; CAMPOS, MÁRCIO; BISPO, MOZART D; KRAUSE, LAIZA C; HERNÁNDEZ MACEDO, MARIA; LOPEZ, JORGE A. Production of xanthan gum from soybean biodiesel: a preliminary study. BMC Proceedings, v. 8, p. P174.
BRANDAO, L. V.; ASSIS, D. J.; LÓPEZ, J. A. ESPIRIDIAO, M. C. A.; ECHEVARRIA, E. M.; Druzian, J.I. Bioconversion from crude glycerin by Xanthomonas campestris 2103: xanthan production and characterization. Brazilian Journal of Chemical Engineering (Impresso), v. 30, p. 737-746.
ALMEIDA, TARCIANA MOURA; BISPO, MOZART D.; CARDOSO, ANE RAQUEL T.; MIGLIORINI, MARCELO VIEIRA; SCHENA, TIAGO; DE CAMPOS, MARIA CECÍLIA VAZ; MACHADO, MARIA ELISABETE; López, Jorge A.; KRAUSE, LAÍZA CANIELAS; CARAMAO, E.B. PRELIMINARY STUDIES OF BIO-OIL FROM FAST-PYROLYSIS OF COCONUT FIBERS. Journal of Agricultural and Food Chemistry, v. 61, p. 6812-6821.
SANTOS, S. C. O. ; LÓPEZ, J. A. ; MEIRA, M. ; GUEDES, M. T. B. ; DAVID, J.M. ; ZACHARIAS, F. ; DAVID, J.P. ; LIMA, F. W. M. . Haemonchus contortus protease inhibition by n-alkyl ferulates from Maprounea guianensis. Research in Veterinary Science, v. 92, p. 492-493.
Borges-dos-Santos, Roberto Robson; LÓPEZ, J. A.; Santos, Luciano C.; Zacharias, Farouk; Davis, Jorge Maurício; David, Juceni Pereira; Lima, Fernanda Washington de Mendonça. Biological Effect of Leaf Aqueous Extract of Caesalpinia pyramidalis in Goats Naturally Infected with Gastrointestinal Nematodes. Evidence-Based Complementary and Alternative Medicine (Print), v. 2012, p. 1-6.
Souza, A.P.A.; LÓPEZ, J. A.; Moura DL; Mendonça-Lima FW. Influência de diferentes condições de armazenamento sob congelamento na reatividade de anticorpos séricos. Revista Brasileira de Analises Clinicas, v. 44, p. 39-43.
Brito, N.J.N.; LÓPEZ, J. A. ; NASCIMENTO, M.A. ; MACEDO, J. B. M. ; Silva GA ; OLIVEIRA, C. N. ; REZENDE, A. A. ; BRANDAO-NETO, J. ; SCHWARZ, A. ; ALMEIDA, M.G. . Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats. Food and Chemical Toxicology, v. 50, p. 4340-4347.
Silva GA; LIMA, W. Q. F.; GUEDES, A. S.; LÓPEZ, J. A. Avaliação da letalidade e atividade antimicrobiana de extratos de folhas de Spondias mombin aff. tuberosa. FACIDER Revista Científica, v. 1, p. 1-18.
Hernandez Macedo, Maria; CONTRERAS-CASTILLO, C. J.; SIU MUI TSAI; CRUZ, S. H.; PADULA, M; SARANTÓPOULUS, C; DIAS, C. T. Gases and volatile compounds associated with microorganisms in blown pack spoilage of Brazilian vacuumpacked beef. Letters in Applied Microbiology, v. 55, p. 467-475.
Souza, Carolina O.; Silva, Luciana T.; Silva, Jaff R.; LÓPEZ, J. A.; Veiga-Santos, Pricila; Druzian, Janice I. Mango and Acerola Pulps as Antioxidant Additives in Cassava Starch Bio-based Film. Journal of Agricultural and Food Chemistry, v. 59, p. 2248-2254.
Hernandez Macedo, Maria; BARANCELLI, G. V; CONTRERAS-CASTILLO, C. J.Microbial deterioration of vacuum-packaged chilled beef cuts and techniques for microbiota detection and characterization: a review. Brazilian Journal of Microbiology (Impresso), v. 42, p. 1-11.
Guedes, M.T. ; ZACHARIAS, F.; Couto, R.D.; Portela, R.W.; Santos, L.C.S. ; Santos, S.C.O.; Pedroza, K.C.; Peixoto, A.P.C.; López, J.A.; Mendonça-Lima, F.W. Maternal transference of passive humoral immunity to Haemonchus contortus in goats. Veterinary Immunology and Immunopathology (Print), v. 136, p. 138-143.
OLIVEIRA, L. C. P.; ARAUJO, R. R.; ALVES, C. R.; MOUTA-CONFORT, E.; LÓPEZ, J. A.; Mendonça-Lima FW. Seroprevalence and risk factors for canine visceral leishmaniasis in the endemic area of Dias D'Ávila, State of Bahia, Brazil. Revista da Sociedade Brasileira de Medicina Tropical (Impresso), v. 43, p. 400-404.
Lima MM; LÓPEZ, J. A.; DAVID, J.M.; Silva EP; Giulietti A.M.; de Queiroz LP; DAVID, J.P. Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala. Planta Médica, v. 75, p. 335-337.
Santos, Sílvia C.O.; David, Juceni P.; David, Jorge M.; López, Jorge A.; Zacharias, Farouk; Guedes, Maria T.B.; de Mendonça Lima, Fernanda W. Inhibition of Haemonchus contortus hemoglobinolytic activities by N-alkyl ferulates from Maproumea guianensis. Veterinary Immunology and Immunopathology (Print), v. 128, p. 290-291.
MIELNICZKI-PEREIRA, A.A.; CHIAVEGATTO, C. W. M.; LÓPEZ, J. A.; COLLI, W.; ALVES, M. J.; GADELHA, F. R. Trypanosoma cruzi strains, Tulahuen 2 and Y, besides the difference in resistance to oxidative stress, display differential glucose-6-phosphate and 6-phosphogluconate dehydrogenases activities. Acta Tropica, v. 101, p. 54-60.
NASCIMENTO, M.A.; SILVA, A.K.; FRANÇA, L. C. B.; QUIGNARD, E. L. J.; LÓPEZ, J. A.; ALMEIDA, M.G. Turnera ulmifolia L. (Turneraceae): Preliminary study of its antioxidant activity. Bioresource Technology, Londres, v. 97, n.12, p. 1387-1391.
FINZI, J. K. ; CHIAVEGATTO, C. W. M. ; CORAT, K. C. F.; LÓPEZ, J. A. ; CABRERA, O. G.; MIELNICZKI-PEREIRA, A. A.; COLLI, W.; ALVES, M.J. M.; GADELHA, F. R. Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide. Molecular and Biochemical Parasitology, Holanda, v. 133, p. 37-43.
LÓPEZ, J. A.; SOUZA, A.M.F. Insulin or insulin-like studies on unicellular organisms: a review. Brazilian Archives of Biology and Technology (Impresso), Curitiba, v. 47, n.6, p. 973-981.
Hernandez Macedo, Maria; MELLO, M. P.; OTTOBONI, L. M. M.; FERRAZ, A.; RODRÍGUEZ, J. Iron-regulated proteins inPhanerochaete chrysosporium andLentinula edodes: Differential analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis and two-dimensional polyacrylamide gel electrophoresis profiles. Electrophoresis (Weinheim. Print), USA, v. 23, n.4, p. 655-661.
LÓPEZ, J. A.; GUERRERO, S. A.; STEINERT, P.; MONTEMARTINI, M.; KALISZ, H.M.; COLLI, W.; SINGH, M.; ALVES, M.J. M.; FLOHÉ, L. His-tagged tryparedoxin peroxidase of Trypanosoma cruzi as a tool for drug screening. Applied Microbiology and Biotechnology, Estados Unidos, v. 53, p. 410-414.
LÓPEZ, J. A.; CARVALHO, T. U.; SOUZA, W.; FLOHÉ, L.; GUERRERO, S. A. ; MONTEMARTINI, M. ; KALISZ, H.M. ; NOGOCEKE, E. ; SINGH, M. ; ALVES, M.J. M.; COLLI, W. . Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi. Free Radical Biology & Medicine, Estados Unidos, v. 28, n.5, p. 767-772.
